Olga Anisimova
Assistant professor of occupational and rehabilitation medicine Medical University
Rheumatoid arthritis, osteoarthritis, gout, spondylitis, osteoporosis - these
disease characterized by inflammatory and degenerative changes
connective tissue (CT) joints or periarticular areas. In the approaches to their
treatment, despite differences in etiology and clinical manifestations, there is
much in common. There are currently few therapeutic schemes - from
medical exposure to different types of surgery.
Has gained the experience of the integrated application of biologically active food supplements
(BAA) under the joint pathology.
To date, accumulated enough evidence to show
the decisive role of nutrition in the development of pathology of the locomotor apparatus.
Therefore, both in treatment and in prevention of these diseases is necessary
Correction supply. And here is justified as the use of dietary supplements to maintain
the normal functioning of ST, including cartilage and bone, and to reduce
risk of degenerative changes in joints.
According to recent studies, the effective maintenance of normal
functioning of the musculoskeletal system is expedient to use supplements to
based on enzymes, particularly proteolytic (bromeline, papain, pepsin,
trypsin chemotripsin, etc.). It is known that enzymes have analgesic,
anti-inflammatory, anti, antiplatelet, and fibrinolytic
immunomodulating effects.
The latter property is especially important because most diseases
musculoskeletal system are autoimmune in nature. Enzymes block
increased activity of the immune system and contribute to the removal of immune
complexes responsible for inflammation. Good results are observed when
using BAA-complexes, including enzymes of different orientation
action in combination with flavonoids (bromelain, protease, amylase, astin).
Protective action on bone and cartilage have also
glyukozaminoglikany that make up the main substance ST. Most important for
metabolic processes of osteo-articular system of chondroitin sulfate, glucosamine,
hyaluronic acid.
Chondroitin sulfate (CS) - has a modifying effect on cartilage and bone
fabric and is included in their stascture. It is localized in the skin, tendons, ligaments,
heart valves, vascular wall, bone, cornea. LDL contains
comprises glucuronic acid, which creates an electronegative charge,
promotes the binding of water, which softens the load on the joint and provides
fluency and flexibility movements, and also fixes the cations of calcium and other
minerals. Therefore better to use CS in combination with calcium supplementation for
accumulation of calcium in the centers of ossification.
Glucosamine (GS) - aminomonosaharid, is a substrate synthesis
glyukozaminoglikanov. HS stimulates the biosynthesis of glyukozaminoglikanov (proteoglycans)
promotes the incorporation of sulfur into cartilage, has protective properties in
concerning the effect of corticosteroids and NSAIDs on chondrocytes, inhibit collagenase
and phospholipase A2, destroying CT, and also affects the state of cartilage tissue
tendons and the formation of intra-articular fluid. Decrease in its synthesis in
body may be the main cause of osteoarthritis (OA) to the initial signs
which include stiffness of the joints in the morning.
CS and HS, have anti-inflammatory, hondroprotektivny, immunomodulatory
and secondary analgesic effects. Unlike traditional medicines
dasgs used for arthritis and OA, which action is directed at
knocking of the secondary inflammatory process in the underlying disease, cholesterol and
HS block pathogenic mechanism leading to degeneration of joints.
Stascturally modifying the activity of CS and HS develops gradually, so
normalization of metabolic processes in the subchondral bone and cartilage
appropriate duration of use (from 3 months. up to 3 years). If at a reception
NSAID pain after 1-2 months. treatment is significantly reduced, and again
increases, that it requires continuous reception, the effect of taking CS and HS
developsmoreslowly (at least restore the cartilage), but ismorepronounced
by the end of the third month of treatment and maintained at 80-85% of patients within 3 months
after treatment. It is therefore quite justified exchange application CS and HS:
3-4-Month reception on 500-1000 mg / day. followed by a 2-3-month hiatus.
CS and HS can be recommended as a dietary supplement to the diet with
prophylactic measure for people older than 30 years, since the age of content
moisture in the cartilage decreases, which leads to a violation of its integrity and Development
osteoarthritis, OA and other diseases. These substances, along with the dasgs
Calcium is needed for the integrated prevention of osteoporosis.
The main constasction material for the mineral matrix of bone is
calcium, the daily need for it in the middle of 1000 mg / day. When
inflammatory conditions (including in the joints), fractures, diseases of the digestive tract,
leading to a breach of its assimilation, pathology of parathyroid and thyroid glands,
adrenal taking certain dasgs content of calcium in the diet
should be increased to 1500-2000 mg / day.
Calcium is well absorbed in the form of citrate, lactate, gluconate and chloride in
complex with proteins. Thus, calcium citrate and protein form a highly soluble and
complexes are readily absorbed calcium lactate and the pH of urine
preventing the formation of phosphoass-calcium salts in the kidneys.
It can be concluded that the diversity of the components in dietary supplements,
allows you to choose the most appropriate track for each patient,
Depending on the availability of the different risk factors for disease
musculoskeletal system.
Source: information-analytical portal " Remedium.com ".