sludge, often increases susceptibility to bacterial and fungal infections.

terms of the number of neutrophils in the blood (the total number of white blood cells multiplied by the percentage of neutrophils) and, accordingly, the risk of infection distinguish between light (1000 - 2000 of neutrophils in 1 mm), medium (500 - 1000/mkl) and severe neutropenia (less than 500/mkl). Severe acute neutropenia caused by a violation of Education of neutrophils, often poses a risk to life.

reasons. Neutropenia is a consequence of breach formation of neutrophils, the regional state of neutrophils (congestion at the walls of blood vessels) with redistribution of blood, their rapid recovery and reduce the lifetime. The condition may be acute (developing over several days) or chronic (lasts months or years). Sometimes this is an isolated anomaly, but in other cases - a manifestation of hematologic (blood-related) diseases.

Most common cause of neutropenia - neutrophil depression education dasgs (such as cytotoxic antitumor agents, anticonvulsants, sulfonamides, etc . etc.). Neutropenia refers to an inevitable side effect of some antitumor dasgs (eg alkylating agents, antimetabolites). Other dasgs cause neutropenia as an idiosyncratic reaction (does not depend on the dosage or duration of the medication).

Reduction of neutrophil production is also observed in some rare hereditary and congenital anomalies (eg, hereditary agranulocytosis in children during the first months of life, when familial neutropenia, cyclic neutropenia, in some diseases in which the violation of the production of neutrophils combined with a severe immunodeficiency). Sometimes the formation of neutrophils disaspted due to a bone marrow transplant or destasction (eg, cancer and granulomatous disease) as well as the usual manifestation of severe vitamin A deficiency in ₁₂ and folate.

manifestations. Neutropenia has no specific manifestations, except for those associated with the proceeding against it and the infection usually depends on the severity, duration and causes of neutropenia. In acute neutropenia fever are not uncommon, the appearance of painful ulcers on the mucous membrane of mouth and anus, the development of bacterial pneumonia. If you do not start treatment in the future there develops bacteremia and septic shock. Chronic neutropenia is often farmorebenign, especially if it is a mild or moderate form, the number of monocytes in the blood normally, and the functions of other immune system components (eg immunoglobulins, complement and lymphocytes) are not changed.

Treatment by a doctor. Gargle every few hours with saline or hydrogen peroxide, pain relievers, lozenges (benzocaine, 15 mg every 3 - 4 h) or rinse the mouth of 1% chlorhexidine ease discomfort associated with ulceration.

Chronic neutropenia - tactics should be expectant: patients should be warned that he should immediately seek medical attention when the temperature rises and other signs of infection.

something interesting

neutropenia (agranulocytosis) occurs (as a side effect), using very high doses of captopril (hood) of patients with connective tissue and impaired renal function after 3 - 6 months of beginning treatment. Typically, the number of leukocytes recovered within three months after the abolition of dasgs.