Thrombocytopenia (continued)

recognizable, and as a consequence, the immune system, being constantly on guard, immediately produces against its own, but the" unrecognized "platelet antiplatelet antibodies. This disease occurs in healthy people before this. A similar syndrome may be associated with chronic lymphocytic leukemia, lymphoma, systemic lupus erythematosus. Detectable at the level of platelet count often falls below 50,000 in 1 mm. Same number of megakaryocytes in the bone marrow remains normal or slightly elevated. It should be noted that the chronic form of the disease is noted, usually in adults and in this case is not always possible to identify provoking factor, but the acute form (immune thrombocytopenic purpura) develops most often in children 10-15 days after undergoing a viral infection. This form of the disease tends to spontaneously terminated within six months - usually within 5-6 weeks. Immune thrombocytopenic purpura - is the most frequent violation of hemostasis in children. In chronic spontaneous remissions are rare, the vast majority of patients with complete or partial remission was observed either in the application of glucocorticoids, or after surgery - removal of the spleen (splenectomy). Glucocorticoid medications prescribed immediately after the detection of signs of thrombocytopenia. Dosages intentionally do not call, because the appointment of glucocorticoids is not the prerogative of the very sick man. To increase the platelet count in peripheral blood is needed, generally two-week therapy with glucocorticoids. And once the platelet count ismorethan 100000 in the 1 ml dose of glucocorticoid dasg gradually reduced. Complete remission after treatment with glucocorticoids is seen in only a quarter of patients. Removing the spleen - splenectomy - satisfied patients who fail to achieve the desired effect of the use of glucocorticoids, or their use can give (have given) serious complications, or whether their application has given a temporary positive effect and thrombocytopenia recurs again and again. In response to numerous letters with questions and issues, statements such as: "My son (daughter, nephew, brother, etc.), our doctors offer surgery to remove the spleen, but we're not sure, should I?" (Or, "but we do not agree ") that's what I say - this operation is often life-saving-threatening bleeding, and I, as an experienced surgeon, I know many instances when relatives did not agree to perform this operation ... Bite your elbows - this in the spirit of our people to Sorry. Usually after a splenectomy are experiencing a rapid rise of the platelet count. I can not say that splenectomy is not harmless and not a simple operation. This operation, once again, is performed only for health reasons - in case of bleeding that is resistant to conservative therapy. Before splenectomy pneumococcal vaccine is administered, and after it - klyukokortikoidnuyu continue therapy until normalization of platelet counts. And only then they were phased out. After surgery, remission occurs in two thirds of patients with chronic form of immune thrombocytopenia. Sometimes there are casuistic cases (as well as without them?). This is when after splenectomy - again a relapse and the reason is the presence of accessory spleen, which can be detected by isotopic methods. In these cases, removal of accessory spleen may lead to remission. Well, if the operation does not lead to success, and if after she retained severe thrombocytopenia with bleeding. Then show immunosuppressive - cyclophosphamide (Cyclophosphamide, Tsitoksan, Endoksan) or Vincristine long courses. In many patients, despite the low platelet count (sometimes even below 30,000 in 1 mm) no severe bleeding. What do I do then? In such cases, long-term immunosuppressant therapy bezosonovatelna. I do not tire of repeating that the treatment of thrombocytopenia without a doctor - very dangerous. Sometimes the increase in the number of platelets in peripheral blood can cause long-term use antigonadotropnyh dasgs (eg danazol, Danola, Danovala). Particularly effective use of the above dasgs in people older than 45 years. In immune thrombocytopenia before the upcoming surgery or for severe bleeding platelet transfusion was shown. But the transfused platelets circulate in the long line - are rapidly destroyed. In these cases apply Immunoglobines. I repeat, I do not specify doses intentionally.

2. Diagnosis of dasg thrombocytopenia is set on the basis of simultaneity of thrombocytopenic purpura and the reception of a particular dasg. So what are the dasgs most likely to be provocative? Here they are: antitumor agents, estrogens, thiazide diuretics, alcohol-containing means, quinidine, heparin, gold preparations, sulfanilaimidy. There is a long-standing asle which can not be ignored - in patients with thrombocytopenia of unknown origin should refuse to accept all medicines, except, of course, without which the patient's life is threatened. Thrombocytopenia often disappears after a few days after eliminating a dasg provoke it, but can sometimes persist for several weeks and even months. For example, preparations of gold is very slowly eliminated from the body.

3. Often in the pages of letters from our readers asked questions - and can it be thrombocytopenia due to blood transfusion or during pregnancy, or "chickenpox" (so often called varicella) in systemic lupus erythematosus, and asbella? Yes, can. After blood transfusion, especially after massive transfusions, or as a result of artificial blood circulation apparatus. Fairly easily corrected by transfusion (transfusion), platelets. And during pregnancy can also be - up to 10% of pregnant women in varying degrees, suffer thrombocytopenia, but usually without serious consequences for the woman and fetus. But be aware that if a woman suffers from chronic immune thrombocytopenia, the child - an increased risk of severe thrombocytopenia that is often detected in the form of intracranial hemorrhage. And while chicken pox can develop and then disappear without a trace. And asbella - rarely, though - one of the 3-4 thousand patients. In systemic lupus erythematosus but thrombocytopenia is noted as a asle, and anemia (anemia) and a decrease in the number of leukocytes (leukopenia). And with cytomegaloviass infection and infectious mononucleosis may develop thrombocytopenia, enlarged spleen (splenomegaly). Although about them as provocateurs of thrombocytopenia in the letters did not ask. But you may ask. From other causes of thrombocytopenia include tuberculosis, cancer (including malignant blood diseases), myelofibrosis, coagulopathy (disturbances in blood coagulation system), lack of vitamin B -12, folic acid, a variety of bacterial, viral and rickettsial infections .
Sadly to say, but the letters come and the people who participated in the liquidation of the Chernobyl accident, ie, in varying degrees, suffered radiation sickness. Kowtow to these people! Yes. In this case develops thrombocytopenia - or rather, pancytopenia - when reduced levels of not only platelets but also of all blood cells, particularly those most sensitive to ionizing radiation - lymphocytes (lymphopenia develops), neutrophils (neutropenia develops), and platelet count - it is clear that develops.

4. But now, the most sad. At the beginning of the note I wrote that this theme becomes painful in the literal and figurative sense. And here's why ... For it is no secret that HIV - infection becomes epidemic. If not already acquired. And the number of HIV-infected persons who are registered does not correspond to the tase number of them. And walk in the flesh of human retroviasses (breaking with the soul and platelets, too, as long as we're talking about it). Thrombocytopenia often is the first manifestation of HIV infection. Along with neutropenia, lymphopenia, and a moderate increase in ESR (erythrocyte sedimentation rate).

5. It must be remembered, and the existence of so-called vascular purpura. This disease develops when the normal functional state of platelets and the normal parameters of blood coagulation system as a result of prolonged glucocorticoid therapy, as well as a simple manifestation of purpura, senile purpura, allergic purpura, scurvy, amyloidosis, globulinemii cold (cryoglobulinemia), Itsenko syndrome - Cushing's (based on of which is the excessive production of corticosteroid hormones, which leads to hypercortisolism). In presenting this material, I have said repeatedly that the treatment of thrombocytopenia should be carried out with the obligatory participation of a physician. Not least because already that in order to be successfully treated properly understand the causes of thrombocytopenia. That's why naming dasgs used in treatment, I avoided specifying dosages. In each case, the doctor will pick up exactly to the patient the appropriate dose. There is not and can not be standardized doses. Scheme is always fraught with danger. Danger of simplistic approach to the treatment of a sick person. You know, what distinguishes doctors from the paramedics (forgive me paramedic!). Or rather, what should they differ from each other. So just what the doctor (I mean the only real doctors are able to think, analyze, synthesize, compassionate, read books that encourage thinking) on biochemical, biophysical, cellular and other levels analyzes the causes of a disease, always trying to climb the very essence of the patient rights (mandatory and given the psychological state). It does not allow the assistant can not do its unwillingness or lack of love for the sick, but simply the lack of deep knowledge, which is able to provide only medical school. Provided if the trainee in him a man wanted to get this knowledge, not just a diploma, allows us to call the doctor.

There is the famous admonition of Herbert Spencer. It reads: "There is a principle that places a barrier in front of any information, he is brought as a proof against any argument, and he can not condemn people to eternal ignorance. This principle is contempt prior to study. " Well, only if the assistant doctor above, if the latter follows the same principle - the principle of contempt prior to investigation. Yes, and not a doctor, he then just a man with a medical degree. This is not the same thing.

And now I'll call medicinal herbs, using which you can fight and win. This: Acacia flowers are white, orange peel, watermelon seeds than usual, Rowan fasits chokeberry (Aronia chokeberry) fasits Peanut underground, tincture of arnica Mountain (careful!), Herb astragalus sherstistotsvetkovogo, infusions and decoctions rhizomes Bergenia crassifolia, tincture and infusion of leaves barberry usual, Amur barberry tincture of leaves, decoction of herbs of Vinca small, juice loosestrife usual, grapes (start with 200 g for 1.5 hours before breakfast, 2 hours before dinner and 1 hour before dinner), powder from dried grape leaves (at 204 g orally) is given as uterine hemostatic, broth peduncles cherry pine, dasgs Merman pepper infusion, herbs, buds and flowers of Carnations fluffy (do not apply to pregnant women at risk of miscarriage), preparations of Geranium sanguineum, preparations from the rhizomes Highlander snake (coil), herbal teas and tinctures from roots and herbs avens city, an ordinary oak bark, infusion, and fresh juice of herbs Dymyanki dasg infusion, Zopnika tubers (1 tablespoon of herbs to fill in 1 cup boiling water and infuse for 4 hours. Take 40-50 ml 3 times a day for 25-30 minutes before meals), infusion Zyuznika European (1 tablespoon of herbs to fill in 200 ml of boiling water. Infuse to cool, then drain. Take 40-50 ml of 4 times a day? hours before the meal ), Yves white - and you can apply tincture and decoction of the bark and the powder (1 g 3-4 times daily before meals).
I note that despite the fancy name of some plants they are all distributed in the territory of our country and not exotic. How to prepare herbal teas, infusions and tinctures are aware, many if not most, evenmoreso in asral areas.

, however, does not asn out of letters, even from the villages of Central Russia, Siberia, with a request to send them a tincture of plantain, or broth Hyperici perforatum. Pardon me, good people. You go on plantain and St. John's Wort. Look at his feet. Read the old (and new) books and manuscripts devoted to these wonderful plants, and other medicines. All the pharmacy at your feet. This is not a call for self-healing. This is a call to a reasonable approach in the treatment of a disease. You can help the doctor to cure themselves or their loved ones. Unless, of course, the doctor is able to cooperate with you (and he should do it) if it is filled with a sincere desire to help you, but does not unmotivated snobbery. I am sure, I know that in Russia a huge number of thoughtful physicians, confidently and skillfully applying and Apitherapy, and herbal medicine, and scalpels, and ... In short, everything that is available in the arsenal of medicine, in the millennial treasury of medical knowledge. The accumulation of medical knowledge began long before Avicenna and Hippocrates. Both then and now, and continue to call the doctor meant, and means will mean a lot. Unless, of course, this kind of soul asshing the floor. If the doctor will not be able to tell a sick person or a seriously ill family member: "What do you want? The disease is incurable and turned quietly away. Well, if, contrary to expectation, you are not very lucky and you have not met a doctor, try to help themselves. People caught in a shipwreck, are able to save his life, not waiting or not waiting for help from emergency services. Such examples innumerable.

Source: online edition of "Planet Health" № 12 January 2004 on the site LTD "MediaRoom" www.ph.com


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