This gel may be retained in the abdominal cavity in sufficient time (which
necessary for the regeneration of damaged peritoneum), thereby delineating the damaged
surface. Gel form of the dasg does not require repeated injections (as compared
with salt, and other colloidal solutions) and does not cause mechanical irritation
with the development of aseptic inflammation (such as solid filmy "barrier"
tools such as Interseed ® and Seprafilm ® ). Furthermore, the stascture
gel can be deposited in its various dasgs that can
enhance the deterrent effect.
In this regard, after surgical
intervention is expected to enter the place probability for the formation of adhesions gel
cellulose ether, which on the one hand separates wound peritoneal surface
On the other hand, contained in its stascture, products will operate
for other pathogenetically relevant links adgeziogeneza.
In connection with the above theoretical
assumptions we carried out a series of experiments, which resulted in failed
show high biological inertness, and expressed preventive properties
methylcellulose gel. The last stage of the experiments was to the simulation
adhesions of the abdominal cavity in two series of Wistar rats and 30 animals
each. The first series was a control group, while the second series after injury
peritoneum to prevent formation of adhesions was used 3% methylcellulose gel
water-soluble. Animals were derived in 14 days by an overdose of ether
anesthesia. Animals were subjected to autopsy, the severity of adhesions was assessed
visually and by semantic differential. In the first series of adhesions
had all the animals, and the second in only four (in the form podpaivaniya gland
the median laparotomic wound). Method of semantic differential expression of
adhesions in the first series was 3,58 ± 0,054 points, while the second 0,021 ± 0,001
(P <0,001).
Thus, the methyl cellulose gel
can effectively prevent the formation of adhesions of the abdominal cavity and complications
associated with the development of adhesions, which may in future find wide
application in clinical practice.
Lipatov, VA Prevention of postoperative
adhesions of the abdominal cavity with indifferent gels. / Collection
Materials I-Russian university
Scientific-practical conference of young scientists and students in medicine. / A
Ed. prof. VG Sapozhnikov., May 29-30, 2002, Tula, Russia.,-C. 121-122.