
aim of this study was to examine the process of formation of postoperative
adhesions of the abdominal cavity in conditions of ischemia and without it.
studies were conducted on white intact Wistar rats,
male, weighing 100 to 120 g. The animals were divided into experimental and
the control group (8 animals in each group). In sterile conditions, under ether
anesthesia was performed median laparotomy. Facing the ventral surface
intestine desirozirovalas with a special tool until the "bloody
Dew, in the experimental group on the peritoneum adjacent to the gut surface of the abdominal wall
superimposed purse string suture to create a regional ischaemia. The animals were derived
from the experiment in 14 days. Upon expiration or termination of the experiment to assess the overall
state of the animal to climb on the total clinical blood analysis, calculated
mielotsitarny index and leukocyte index of intoxication. Then conducted
mortem examination, and the estimated severity of adhesions
process visually and using an automated method of semantic differential.
Complex abdominal organs taken out of a corpse and was fixed in 10%
neutral formalin. Then performed a histological study
standard technique. The obtained data were processed statistically, the results
reflected in tables, graphs and diagrams.
In the control group, the severity of adhesions by
semantic differential was 1,34 ±
0.24 points, while the experimental group the severity of adhesions by semantic
differential amounted to 3,20 ± 0,26 points.
That was statistically significant (P <0,0001).
Thus, the experiment revealed that deserozirovanie
cecum can reliably reproduce the post-operative adhesions
abdominal cavity in the experiment and ischemia in trauma creates additional
conditions for the development of postoperative abdominal adhesions, a statistically
significantly increasing the severity of adhesions.
Lipatov, VA, Glushenko IA Kobelev AA Role of ischemia peritoneum
in the pathogenesis of postoperative abdominal adhesions. Proceedings of the 67 th Inter-University
scientific conference of students and young scientists. In 2 parts. Part 1 .- The Kursk:
CSMU, 2002, sir. 178 - 189.