Role of ischemia in the pathogenesis of abdominal postoperative abdominal adhesions

Islands and to be
  tissues (Theodore E., Miko, I., Nagy, T., 1982; Baibekov IM, Madartov K. Horoshaev
  VA, 1996). Often during the operation of such situations are unavoidable (the imposition of
  terminals, forming anastomoses). In this regard, the study of mechanisms of influence
  tissue ischemia on the formation of postoperative adhesions and the possible ways
  preventing it considers relevant.

aim of this study was to examine the process of formation of postoperative
  adhesions of the abdominal cavity in conditions of ischemia and without it.

studies were conducted on white intact Wistar rats,
  male, weighing 100 to 120 g. The animals were divided into experimental and
  the control group (8 animals in each group). In sterile conditions, under ether
  anesthesia was performed median laparotomy. Facing the ventral surface
  intestine desirozirovalas with a special tool until the "bloody
  Dew, in the experimental group on the peritoneum adjacent to the gut surface of the abdominal wall
  superimposed purse string suture to create a regional ischaemia. The animals were derived
  from the experiment in 14 days. Upon expiration or termination of the experiment to assess the overall
  state of the animal to climb on the total clinical blood analysis, calculated
  mielotsitarny index and leukocyte index of intoxication. Then conducted
  mortem examination, and the estimated severity of adhesions
  process visually and using an automated method of semantic differential.
  Complex abdominal organs taken out of a corpse and was fixed in 10%
  neutral formalin. Then performed a histological study
  standard technique. The obtained data were processed statistically, the results
  reflected in tables, graphs and diagrams.

In the control group, the severity of adhesions by
  semantic differential was 1,34 ±
  0.24 points, while the experimental group the severity of adhesions by semantic
  differential amounted to 3,20 ± 0,26 points.
  That was statistically significant (P <0,0001).

Thus, the experiment revealed that deserozirovanie
  cecum can reliably reproduce the post-operative adhesions
  abdominal cavity in the experiment and ischemia in trauma creates additional
  conditions for the development of postoperative abdominal adhesions, a statistically
  significantly increasing the severity of adhesions.

Lipatov, VA, Glushenko IA Kobelev AA Role of ischemia peritoneum
  in the pathogenesis of postoperative abdominal adhesions. Proceedings of the 67 th Inter-University
  scientific conference of students and young scientists. In 2 parts. Part 1 .- The Kursk:
  CSMU, 2002, sir. 178 - 189.

 

|Views: 364