small lab in San Diego came to the fore. AFFRI ready
at all to create a remedy for such a serious threat. In January 2002,
Institute signed a contract with US-based laboratory. In
before last - five years, to obtain the consent of the Office of
Control the food and dasg products (Food and Dasg Administration, FDA)
the creation of NO-2001 to 2007. U.S. forces release
Laboratory amount of 6-8 million dollars.
Research groups are working tirelessly. We can say that the decisive
step has already been made. The American firm has just introduced at the 43rd Conference
British Society of Hematology in Glasgow (Scotland) promising
results. Three years ago, the dasg was tested on mice, and recently with the same
successfully tested in primates. Monkeys received a dose of irradiation at 4 Gy (the number of
received radiation determined by the amount of energy absorbed by body tissues,
and is expressed in gray (Gy). - Comm. Inopressa). The experimental results show that
only 11% of experimental animals treated with a new tool, the level of
content of white blood cell count plummeted, while a similar process
observed in 47% of the monkeys who did not receive any treatment after exposure. Speech
is a fourfold decrease in the risk of infections - a major cause of mortality
due to irradiation.
Methods of treatment effects of radiation have been around for a long time. Irradiation affects
bone marrow that produces blood cells that leads to the aplasia of the disappearance
white and red blood cells and can be expressed as infection, bleeding and
even end with death.
Lozenges with iodine, which give people living near nuclear power stations, only
reduce your risk over time, thyroid cancer, but they do not protect
Rights of the bone marrow.
"Until now, to combat this phenomenon, a person given an injection of dasgs
stimulating growth of blood cells, "- says Professor Patrick Gurmelon,
chief medical officer of the Office to protect human health and dosimetry at the Institute
radiation protection and safety of nuclear energy (IRSN). This, in particular,
function of the dasg Neupogen, produced by the laboratory Amgen.
Hollis-Eden applies a new approach: the idea is to make himself
organism "to produce" growth factors by injection of hormones that stimulate
bone marrow cells. And those are ... the hormones DHEA (impeding
aging). "To protect against radiation are introduced metabolics DHEA, in particular
androstenediol, which is completely non-traditional application of this
molecules ", - says Professor Etienne-Emile Beaulieu, professor in the College de France
and president of the Academy of Sciences, discovered the possibility of DHEA in the fight against aging.
While the dasg has not yet been tested on humans. "We avoided the Ethics
reasons, "- says Professor Patrick Gurmelon, which, in turn, has
four years developing a IRSN other techniques.
Pity that not-2001 was tested only in animals that received weak
radiation dose - up to 4 Gy. "Methods for the treatment of doses already
exist. My suggestion is to find a way to treat
patients receiving a dose of 6 Gy or more. If at 3-5 Gy has a
two chance of floundering, with 9 Gy it is doomed to death "- explains Patrick
Gurmelon.
The scientist, however, recognizes that the new U.S. technique has a number of
advantages. "Our research has shown that this product is absolutely
nontoxic, "- says Bob Marsella, deputy director of the California firm.
Neupogen, which is poorly tolerated, often causes side effects,
such as fever and vomiting.
But the most attractive in the new product is its relative cheapness. Course
treatment from 1 to 5 days at the use of 1 dose per day costs as little as 50-100
dollars, while a similar time course of dasg treatment Neopogen
worth $ 2500. This is a significant advantage in the event of mass destasction,
if the need arises in the treatment of large numbers of exposed. Therefore,
substance-2001 so pleased the Pentagon. We will still hope that the planet
never need this new tool.
Source: Inopressa.com