British Medical Journal. Harvard doctors found the cause
one of the most severe forms of dilated cardiomyopathy. At the same time
disease of the heart ventricles enlarge and lose their ability to
body needs to pump enough blood, which eventually leads to
heart failure. Usually this abnormality arises as a consequence
coronary heart disease and hormonal disorders, but it can be
called and genetic abnormalities. Dr. Christine Seidman and her colleagues
found that in such cases, the disease most likely caused by
mutation of the gene responsible for synthesis fosfolambana. This protein controls the
work of enzymes that transport calcium ions across cell membranes.
The influx of calcium into the cells of the heart causes it to shrink, but outflows - relaxation.
The researchers did not exclude the possibility that defects in this gene play an important role in
pathogenesis and other types of heart failure.

Source: Svoboda.org