Transurethral resection of the bladder with a fluorescent control

lnyh with urogenital tumors. Is well-known propensity
  RDM to local recurrence. In the first 6-9 months after TUR for primary
  of surface DMS in 20-40% of patients had recurrences of RMP.


in the treatment of the primary surface DMS and its recurrence recognized
  method is transurethral resection (TUR) of bladder. By world
  data, the use of TUR achieves good results of survival of patients
  while maintaining their high social and physical adjustment after surgery.


Regardless of the surgeon's skill superficial bladder tumor
  bladder (urothelium), such as dysplasia or carcinoma in situ, did not cause thickening of the
  wall can easily be missed during surgery. In order to visualize these
  formations, we use fluorescent cystoscopy (FC).


This method is based on instillation (injection) into the bladder
  5-aminolevulinic acid (5-ALA) for 4 hours before surgery. The dasg causes
  to the accumulation of fluorescent porphyrins (mainly protoporphyrin IX) in cells
  urothelium. Due to chemical reactions of metabolism of protoporphyrin IX, a tumor
  tissue observed fluorescence, visible eye when performing cystoscopy.


Bladder Cancer (RMP) is VI-th place among all cancer
  disease, II-nd place among onkourologicheskih diseases and III-rd place in
  mortality among patients with urogenital tumors. Is well-known propensity
  RDM to local recurrence. In the first 6-9 months after TUR for primary
  of surface DMS in 20-40% of patients had recurrences of RMP.


in the treatment of the primary surface DMS and its recurrence recognized
  method is transurethral resection (TUR) of bladder. By world
  data, the use of TUR achieves good results of survival of patients
  while maintaining their high social and physical adjustment after surgery.
  Regardless of the surgeon's skill superficial bladder tumors (urothelial)
  such as dysplasia or carcinoma in situ, did not cause thickening of the wall can be
  easily missed during surgery.


In order to visualize these stasctures, we use fluorescent
  cystoscopy (FC). This method is based on instillation (injection) into the bladder
  5-aminolevulinic acid (5-ALA) for 4 hours before surgery. The dasg causes
  to the accumulation of fluorescent porphyrins (mainly protoporphyrin IX) in cells
  urothelium. Due to chemical reactions of metabolism of protoporphyrin IX, a tumor
  tissue observed fluorescence, visible eye when performing cystoscopy.


RMP cause of relapse after TUR:

      
  • Nediagnostsirovanye and undeleted satellite tumors outside the transurethral
        resection
  •   
  • unremoved bladder mucosa with dysplasia or carcinoma in situ of
        edge of the resection.

cause of relapse after TUR RMP:

      
  • Nediagnostsirovanye and undeleted satellite tumors outside the transurethral
        resection
  •   
  • unremoved bladder mucosa with dysplasia or carcinoma in situ of
        edge of the resection.

in nonspecific inflammation of the bladder dysplasia or carcinoma in
  situ revealed: at cystoscopy in white light - in 53.3%, while FC - 95%.
  Improve treatment outcomes for FC RMP can be achieved by:

      
  • early diagnosis of RMP under the surface of tumor
  •   
  • detecting precancerous changes in the urothelium
  •   
  • maximum efficacy of the treatment (TURP under photodynamic control)
      

Thus, use of FC can significantly improve performance
  Endoscopic diagnosis of urothelial neoplasms, with questionable results
  cytological examination FC can be used for precise localization
  tumor. Conduct tour under photodynamic control reduces the number of
  recurrence of bladder cancer

Elders VJ

               Gorelov SI, Kagan O.F

              

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