
in the treatment of the primary surface DMS and its recurrence recognized
method is transurethral resection (TUR) of bladder. By world
data, the use of TUR achieves good results of survival of patients
while maintaining their high social and physical adjustment after surgery.
Regardless of the surgeon's skill superficial bladder tumor
bladder (urothelium), such as dysplasia or carcinoma in situ, did not cause thickening of the
wall can easily be missed during surgery. In order to visualize these
formations, we use fluorescent cystoscopy (FC).
This method is based on instillation (injection) into the bladder
5-aminolevulinic acid (5-ALA) for 4 hours before surgery. The dasg causes
to the accumulation of fluorescent porphyrins (mainly protoporphyrin IX) in cells
urothelium. Due to chemical reactions of metabolism of protoporphyrin IX, a tumor
tissue observed fluorescence, visible eye when performing cystoscopy.
Bladder Cancer (RMP) is VI-th place among all cancer
disease, II-nd place among onkourologicheskih diseases and III-rd place in
mortality among patients with urogenital tumors. Is well-known propensity
RDM to local recurrence. In the first 6-9 months after TUR for primary
of surface DMS in 20-40% of patients had recurrences of RMP.
in the treatment of the primary surface DMS and its recurrence recognized
method is transurethral resection (TUR) of bladder. By world
data, the use of TUR achieves good results of survival of patients
while maintaining their high social and physical adjustment after surgery.
Regardless of the surgeon's skill superficial bladder tumors (urothelial)
such as dysplasia or carcinoma in situ, did not cause thickening of the wall can be
easily missed during surgery.
In order to visualize these stasctures, we use fluorescent
cystoscopy (FC). This method is based on instillation (injection) into the bladder
5-aminolevulinic acid (5-ALA) for 4 hours before surgery. The dasg causes
to the accumulation of fluorescent porphyrins (mainly protoporphyrin IX) in cells
urothelium. Due to chemical reactions of metabolism of protoporphyrin IX, a tumor
tissue observed fluorescence, visible eye when performing cystoscopy.
RMP cause of relapse after TUR:
cause of relapse after TUR RMP:
in nonspecific inflammation of the bladder dysplasia or carcinoma in
situ revealed: at cystoscopy in white light - in 53.3%, while FC - 95%.
Improve treatment outcomes for FC RMP can be achieved by:
Thus, use of FC can significantly improve performance
Endoscopic diagnosis of urothelial neoplasms, with questionable results
cytological examination FC can be used for precise localization
tumor. Conduct tour under photodynamic control reduces the number of
recurrence of bladder cancer
Elders VJ
Gorelov SI, Kagan O.F